Document Details
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Document Type |
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Article In Journal |
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Document Title |
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dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation dRHP-PseRA: detecting remote homology proteins using profile-based pseudo protein sequence and rank aggregation |
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Document Language |
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English |
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Abstract |
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Protein remote homology detection is an important task in computational proteomics. Some
computational methods have been proposed, which detect remote homology proteins based
on different features and algorithms. As noted in previous studies, their predictive results are
complementary to each other. Therefore, it is intriguing to explore whether these methods can
be combined into one package so as to further enhance the performance power and application
convenience. In view of this, we introduced a protein representation called profile-based pseudo protein
sequence to extract the evolutionary information from the relevant profiles. Based on the concept
of pseudo proteins, a new predictor, called “dRHP-PseRA”, was developed by combining four stateof-
the-art predictors (PSI-BLAST, HHblits, Hmmer, and Coma) via the rank aggregation approach.
Cross-validation tests on a SCOP benchmark dataset have demonstrated that the new predictor
has remarkably outperformed any of the existing methods for the same purpose on ROC50 scores.
Accordingly, it is anticipated that dRHP-PseRA holds very high potential to become a useful high
throughput tool for detecting remote homology proteins. For the convenience of most experimental
scientists, a web-server for dRHP-PseRA has been established at http://bioinformatics.hitsz.edu.cn/
dRHP-PseRA/. |
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ISSN |
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2045-2322 |
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Journal Name |
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Scientific reports |
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Volume |
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6 |
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Issue Number |
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1 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Monday, July 17, 2017 |
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Researchers
| Junjie Chen | Chen, Junjie | Researcher | Doctorate | |
| Ren Long | Long, Ren | Researcher | Doctorate | |
| Xiao-long Wang | Wang, Xiao-long | Researcher | Doctorate | |
| Bin Liu | Liu, Bin | Researcher | Doctorate | |
| Kuo-Chen Chou | Chou, Kuo-Chen | Researcher | Doctorate | |
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